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Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 410-422 doi: 10.1007/s11684-017-0527-6

Abstract:

Aberrant expression of annexin A2-S100A10 heterotetramer (AIIt) associated with PML/RARα fusion/RARα) fusion protein, this work was performed to determine the transcription start site of ANXA2Zinc-induced U937/PR9 cells expressed PML/RARα fusion protein, and resultant increases in ANXA2The transactivation of ANXA2 promoter by PML/RARα fusion protein was 3.29±0.13 fold higherThus, PML/RARα fusion protein transactivated the ANXA2 promoter to upregulate ANXA2 and accumulate

Keywords： annexin A2-S100A10 heterotetramer     PML/RARα fusion protein     plasmin     cell invasion     acute promyelocytic leukemia    

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BRD4 interacts with PML/RARα in acute promyelocytic leukemia

Qun Luo, Wanglong Deng, Haiwei Wang, Huiyong Fan, Ji Zhang

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 726-734 doi: 10.1007/s11684-017-0604-x

Abstract: This protein can be targeted by JQ1, a selective small-molecule inhibitor./RARα) fusion protein to some extent.Moreover, downregulation of PML/RARα at the mRNA and protein levels was observed upon JQ1 treatment.Furthermore, results from the RT-qPCR, ChIP-qPCR, and re-ChIP-qPCR assays showed that BRD4 and PML/RARαHence, we showed a new discovery of the interaction of BRD4 and PML/RARα, as well as the decline of PML

Keywords： BRD4     PML/RARα     APL     interaction    

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Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block

Xiaoling Wang,Yun Tan,Yizhen Li,Jingming Li,Wen Jin,Kankan Wang

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 420-429 doi: 10.1007/s11684-016-0478-3

Abstract: kinase inhibitor 2C (CDKN2C) as a member of the cyclin-dependent kinase inhibitors is a target of the PML/RARα oncofusion protein in leukemogenesis of acute promyelocytic leukemia (APL)./RARα directly bound to the CDKN2C promoter in the APL patient-derived cell lineLuciferase assays indicated that PML/RARα inhibited the CDKN2C promoter activityFurthermore, all-trans retinoic acid treatment induced CDKN2C expression by releasing the PML/RAR&alpha

Keywords： CDKN2C     acute promyelocytic leukemia     cell cycle arrest     differentiation    

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Regulatory mechanism and functional analysis of

Yonglan Zhu,Fang Zhang,Shanzhen Zhang,Wanglong Deng,Huiyong Fan,Haiwei Wang,Ji Zhang

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 87-96 doi: 10.1007/s11684-016-0469-4

Abstract:

S100A9, a calcium-binding protein, participates in the inflammatory process and development of variousWe used real-time quantitative PCR to determine whether PML/RARα affects the expression of in NB4ChIP-based PCR and dual-luciferase reporter assay system were used to detect how PML/RARα and PUResults showed that was an ATRA-responsive gene, and PML/RARα was necessary for the ATRA-inducedCollectively, our data indicated that PML/RARα and PU.1 were necessary for the ATRA-induced expression

Keywords： S100A9 S100A9     PU.1     PML/RARα     ATRA     APL    

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Prokaryotic expression and purification of fusion protein HSP70-EGFP and its application in the study

QU Ping, SUI Yanfang, MA Jiahai, CHEN Guangsheng, LIU Libing, CHEN Jiankang, LIU Fang'e

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 82-86 doi: 10.1007/s11684-008-0015-0

Abstract: To study the endocytic activity of dendritic cells (DCs) by obtaining fusion protein HSP70-EGFP as exogenousFusion protein HSP70-EGFP was prokaryotically expressed, isolated and purified.Fusion protein HSP70-EGFP was successfully obtained and its molecular weight was 97 000.It accounted for 35.32% of the total protein.Under irradiation of an ultraviolet lamp, the protein solution sent out viridescent fluorescence.

Keywords： significant difference     irradiation     peripheral     preliminary     EGFP    

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Magnetic confinement fusion: a brief review

Chuanjun HUANG, Laifeng LI

Frontiers in Energy 2018, Volume 12, Issue 2,   Pages 305-313 doi: 10.1007/s11708-018-0539-1

Abstract: Fusion energy is considered to be the ultimate energy source, which does not contribute to climate changeDuring the past several decades, never-ceasing efforts have been made to peacefully utilize the fusionIn this paper, the main developments of magnetic confinement fusion with emphasis on confinement systemsThe scientific feasibility of magnetic confinement fusion has been demonstrated in JET, TFTR, JT-60,A fusion roadmap to DEMO and commercial fusion power plant has been established and steady progresses

Keywords： fusion energy     magnetic confinement     tokamak     structural material     superconducting magnet    

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Turbidity-adaptive underwater image enhancement method using image fusion

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 3, doi: 10.1007/s11465-021-0669-8

Abstract: Clear, correct imaging is a prerequisite for underwater operations. In real freshwater environment including rivers and lakes, the water bodies are usually turbid and dynamic, which brings extra troubles to quality of imaging due to color deviation and suspended particulate. Most of the existing underwater imaging methods focus on relatively clear underwater environment, it is uncertain that if those methods can work well in turbid and dynamic underwater environments. In this paper, we propose a turbidity-adaptive underwater image enhancement method. To deal with attenuation and scattering of varying degree, the turbidity is detected by the histogram of images. Based on the detection result, different image enhancement strategies are designed to deal with the problem of color deviation and blurring. The proposed method is verified by an underwater image dataset captured in real underwater environment. The result is evaluated by image metrics including structure similarity index measure, underwater color image quality evaluation metric, and speeded-up robust features. Test results exhibit that the method can correct the color deviation and improve the quality of underwater images.

Keywords： turbidity     underwater image enhancement     image fusion     underwater robots     visibility    

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M-LFM: a multi-level fusion modeling method for shape−performance integrated digital twin of complex

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 4, doi: 10.1007/s11465-022-0708-0

Abstract: developing a new digital twin framework that includes simulation data, measuring data, multi-level fusion

Keywords： shape−performance integrated digital twin (SPI-DT)     multi-level fusion modeling (M-LFM)     surrogate model     telescopic boom crane     data fusion    

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Gradient-based compressive image fusion

Yang CHEN,Zheng QIN

Frontiers of Information Technology & Electronic Engineering 2015, Volume 16, Issue 3,   Pages 227-237 doi: 10.1631/FITEE.1400217

Abstract: We present a novel image fusion scheme based on gradient and scrambled block Hadamard ensemble (SBHE)In the fusion phase, the image gradient is calculated to reflect the abundance of its contour informationFinally, inverse transformation is applied to the coefficients derived from fusion, and the fused imagequality in line with different fusion schemes.Furthermore, the gradient-based fusion scheme proposed in this paper can be applied in different fusion

Keywords： Compressive sensing (CS)     Image fusion     Gradient-based image fusion     CS-based image fusion    

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Information fusion in aquaculture: a state-of the art review

Shahbaz Gul HASSAN,Murtaza HASAN,Daoliang LI

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 3,   Pages 206-221 doi: 10.15302/J-FASE-2016111

Abstract: In this review, an information fusion approach was used to integrate multi-sensor and computer visionInformation fusion is a well-known technology that has been used in different fields of artificial intelligenceInformation fusion in aquaculture is a growing field of research that is used to enhance the performanceThis review study surveys different fish feeding systems using multi-sensor data fusion, computer vision

Keywords： aquaculture     computer vision     information fusion     modeling     sensor    

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Iterative HOEO fusion strategy: a promising tool for enhancing bearing fault feature

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 1, doi: 10.1007/s11465-022-0725-z

Abstract: To address these issues, this paper presents a novel EO fusion strategy for enhancing the bearing faultMDIM is regarded as the fusion source of the proposed strategy with the properties of improving the signal-to-interferenceenhancing the bearing fault feature than the existing methods, including HOEOs, the weighting HOEO fusion

Keywords： higher order energy operator     fault diagnosis     manifold learning     rolling element bearing     information fusion    

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Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 2,   Pages 102-112 doi: 10.15302/J-FASE-2016100

Abstract: great opportunity to explore plant–pathogen interactions from a systems perspective and studies on protein–protein

Keywords： plant–pathogen interactions     systems biology     omics     plant immunity     protein–protein interaction     network    

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Contact detection with multi-information fusion for quadruped robot locomotion under unstructured terrain

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 3, doi: 10.1007/s11465-023-0760-4

Abstract: quadruped robots, a detection approach based on the probabilistic contact model with multi-information fusion

Keywords： multi-information fusion     contact detection     quadruped robot     probabilistic contact model     unstructured    

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Analysis of spinal lumbar interbody fusion cage subsidence using Taguchi method, finite element analysis

Christopher John NASSAU, N. Scott LITOFSKY, Yuyi LIN

Frontiers of Mechanical Engineering 2012, Volume 7, Issue 3,   Pages 247-255 doi: 10.1007/s11465-012-0335-2

Abstract: Anterior lumbar interbody fusion (ALIF) cages may subside into the vertebral body and lead to kyphoticprevious studies have utilized an artificial neural network (ANN) for the design of a spinal interbody fusionTherefore, the Taguchi-FEA-ANN approach can serve as an effective procedure for designing a spinal fusion

Keywords： anterior lumbar interbody fusion (ALIF)     artificial neural network (ANN)     finite element     interbody cage     lumbar interbody fusion     subsidence     taguchi method    

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Development and testing of a wireless smart toolholder with multi-sensor fusion

Frontiers of Mechanical Engineering 2023, Volume 18, Issue 4, doi: 10.1007/s11465-023-0774-y

Abstract: In this study, we propose a wireless smart toolholder with multi-sensor fusion for simultaneous sensingWe select force, vibration, and temperature sensors suitable for smart toolholder fusion to adapt to

Keywords： wireless smart toolholder     multi-sensor fusion     circular runout     dynamic balancing     static stiffness    

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Title Author Date Type Operation

Annexin A2-S100A10 heterotetramer is upregulated by PML/RARα fusion protein and promotes plasminogen-dependent

Dan Huang, Yan Yang, Jian Sun, Xiaorong Dong, Jiao Wang, Hongchen Liu, Chengquan Lu, Xueyu Chen, Jing Shao, Jinsong Yan

Journal Article

BRD4 interacts with PML/RARα in acute promyelocytic leukemia

Qun Luo, Wanglong Deng, Haiwei Wang, Huiyong Fan, Ji Zhang

Journal Article

Repression of CDKN2C caused by PML/RARα binding promotes the proliferation and differentiation block

Xiaoling Wang,Yun Tan,Yizhen Li,Jingming Li,Wen Jin,Kankan Wang

Journal Article

Regulatory mechanism and functional analysis of

Yonglan Zhu,Fang Zhang,Shanzhen Zhang,Wanglong Deng,Huiyong Fan,Haiwei Wang,Ji Zhang

Journal Article

Prokaryotic expression and purification of fusion protein HSP70-EGFP and its application in the study

QU Ping, SUI Yanfang, MA Jiahai, CHEN Guangsheng, LIU Libing, CHEN Jiankang, LIU Fang'e

Journal Article

Magnetic confinement fusion: a brief review

Chuanjun HUANG, Laifeng LI

Journal Article

Turbidity-adaptive underwater image enhancement method using image fusion

Journal Article

M-LFM: a multi-level fusion modeling method for shape−performance integrated digital twin of complex

Journal Article

Gradient-based compressive image fusion

Yang CHEN,Zheng QIN

Journal Article

Information fusion in aquaculture: a state-of the art review

Shahbaz Gul HASSAN,Murtaza HASAN,Daoliang LI

Journal Article

Iterative HOEO fusion strategy: a promising tool for enhancing bearing fault feature

Journal Article

Systems understanding of plant–pathogen interactions through genome-wide protein–protein interaction

Hong LI,Ziding ZHANG

Journal Article

Contact detection with multi-information fusion for quadruped robot locomotion under unstructured terrain

Journal Article

Analysis of spinal lumbar interbody fusion cage subsidence using Taguchi method, finite element analysis

Christopher John NASSAU, N. Scott LITOFSKY, Yuyi LIN

Journal Article

Development and testing of a wireless smart toolholder with multi-sensor fusion

Journal Article